Virus-associated Inflammation Imprints an Inflammatory Profile on Long-lived Monocyte-derived Macrophages in the Human Liver
J.-D. Sanchez, S. Nkongolo, D. Traum, S. C. Kim, D. Mahamed, A. Mehrotra, A. Patel, D. Chen, S. Fung, A. Gaggar, J. J. Feld, K.-M. Chang, J. J. Wallin, H. L. A. Janssen, A. J. Gehring
The paper shows that chronic inflammation in the liver leads to the formation of long-lived inflammatory macrophages derived from monocytes, which retain an inflammatory profile and may drive liver disease progression.
bioRxiv · Jan 31, 2024 · PreprintImmunology