A. Patel

Immune-profiling of T helper 1 (Th1), Th2 and Th17 signatures in murine splenocytes by targeting intracellular cytokines

The paper develops a 17-parameter spectral flow cytometry panel to profile Th1, Th2, and Th17 cytokine signatures in murine splenocytes under steady-state and stimulated conditions.

Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation

This study uses mechanical oscillation to enhance endosomal escape of mRNA delivered by lipid nanoparticles, improving transfection efficiency without harming cell viability or organelle integrity.

mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity

This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells

This study compares cytokine production kinetics in TCR-T cells and CAR-T cells with and without co-stimulation, finding that 2nd-generation CAR-T cells sustain cytokine production without co-stimulation.

WildPose: A Long-Range 3D wildlife motion capture system

WildPose enables long-range 3D motion capture of wildlife for ecological and biomechanical studies, demonstrating accurate tracking and morphological analysis in field trials.

Virus-associated Inflammation Imprints an Inflammatory Profile on Long-lived Monocyte-derived Macrophages in the Human Liver

The paper shows that chronic inflammation in the liver leads to the formation of long-lived inflammatory macrophages derived from monocytes, which retain an inflammatory profile and may drive liver disease progression.

Multiplexed Short-wave Infrared Imaging Highlights Anatomical Structures in Mice

This study develops three-color SWIR quantum dot imaging in mice to visualize lymphatic and vascular networks with high resolution and multiplexing capability.

Trade-off Between Resistance and Persistence in High Cell Density Escherichia Coli Cultures

The paper investigates high cell density physiology in Escherichia coli, revealing a trade-off between resistance and persistence through transcriptional analysis and machine learning.

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

Integrating Shear Flow and Trypsin Treatment to Assess Cell Adhesion Strength

This paper introduces a shear flow assay with trypsin treatment to assess cell adhesion strength, showing that shear stress between 0.07 and 7 Pa can dislodge strongly adherent cells.

Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

This study shows that allelic bias in GINS4 variants contributes to variable clinical and cellular phenotypes in NK cell deficiency.

Formin tails act as a switch, inhibiting or enhancing processive actin elongation

The paper investigates how tail domains in formins regulate actin assembly through alternative splicing, showing that some tails inhibit processive elongation while others enhance it.

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

Clinical Knowledge and Reasoning Abilities of AI Large Language Models in Pharmacy: A Comparative Study on the NAPLEX Exam

This study evaluates three LLMs on a NAPLEX exam, finding GPT-4 performs best but struggles with multi-select questions.

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

Revisiting the role of Acinetobacter sp. in EBPR systems

The paper investigates the role of Acinetobacter in EBPR systems using 16S sequencing and SCRS-FISH, finding Acinetobacter dominance and its contribution to phosphorus removal under specific operational conditions.

Comammox and Unknown Candidate AOBs Contribute to Nitrite Accumulation in An Integrated A-B stage process that Incorporates Side-stream EBPR (S2EBPR)

The paper demonstrates an integrated wastewater treatment process that achieves nitrite accumulation through comammox and unknown AOBs, revealing their role in short-cut nitrogen removal.

Mutagenic-end joining results in smaller deletions in heterochromatin relative to euchromatin

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

Proteome allocation is linked to transcriptional regulation through a modularized transcriptome

The paper investigates modularization of bacterial transcriptomes and proteomes to uncover relationships between their compositions and regulatory mechanisms.

Chronic industrial perturbation and seasonal change induces shift in the bacterial community from gammaproteobacteria to betaproteobacteria at Amlakhadi canal

The study examines seasonal shifts in bacterial communities at Amlakhadi canal, showing a shift from Gammaproteobacteria to Betaproteobacteria in response to industrial pollution and seasonal changes.

Immune response modulation by Pseudomonas aeruginosa persister cells

This study shows Pseudomonas aeruginosa persister cells evade host innate immunity by resisting complement-mediated killing and inducing a shift in macrophage polarization from M2 to M1 over time.

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

This study identifies the molecular mechanism of autophagy initiation by revealing the role of metamorphic proteins ATG13-101 in forming the autophagy initiation supercomplex.

Salivary exosomal miR-1307-5p predicts disease aggressiveness and poor prognosis in oral squamous cell carcinoma patients

This study identifies miR-1307-5p in salivary exosomes as a prognostic marker for poor survival and disease aggressiveness in oral squamous cell carcinoma.

Drug-induced adaptation along a resistance continuum in cancer cells

This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.

A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma

This study identifies a 3-miRNA signature in salivary exosomes that predicts OSCC progression and reveals its role in regulating EMT and tumor cell behavior.

In vivo selection reveals long non-coding RNAs implicated in colon to liver metastasis

This study identifies lncRNAs associated with colon cancer metastasis to the liver by comparing highly metastatic and less metastatic cells.