Author

Jack Coomes

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Izadora Liranço FurlaniiD· 2 shared Karen H. VousdeniD· 2 shared Vassilis PapalazarouiD· 2 shared Francesco Saverio TedescoiD· 1 shared Lucia RossiiD· 1 shared Martha M. ZarouiD· 1 shared Valentina Maria LionelloiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Izadora Liranço FurlaniORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NAD+ limitation and α-ketoglutarate depletion define cancer induced muscle atrophy

Vassilis Papalazarou, Jack Coomes, Lucia Rossi, Valentina Maria Lionello, Izadora Liranço Furlani, Francesco Saverio Tedesco, Karen H. Vousden

This study identifies NAD+ limitation and α-ketoglutarate depletion as mechanisms by which pancreatic cancer cells induce muscle atrophy through metabolic rewiring and redox imbalance.

bioRxiv · Oct 16, 2026 · PreprintCancer Biology

Dietary serine and glycine restriction delays cancer-associated cachexia

Vassilis Papalazarou, Jack Coomes, Martha M. Zarou, Izadora Liranço Furlani, Karen H. Vousden

This study shows that dietary serine and glycine restriction delays cancer-associated cachexia in mice by altering host metabolism and reducing inflammation, independent of tumor growth.

bioRxiv · Oct 16, 2026 · PreprintCancer Biology