Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia.
David A. Figge, Henrique de Amaral Oliveira, Jack Crim, Rita Marie Cowell, David G. Standaert, Karen L. Eskow Jaunarajs
This study identifies differential activation states of D1-MSN subpopulations in response to L-DOPA treatment and links these changes to LID development through activin/TGFβ signaling.
bioRxiv · Nov 3, 2023 · PreprintNeuroscience