Author

Jack Dent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Research Focus:software / tool· 3 Research Focus:benchmarking· 2 Assay:protein sequence· 2 Assay:protein structure· 2 Approach:diffusion model· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alex RogozhnikoviD· 3 shared Jacques BoitreaudiD· 3 shared Joshua MeieriD· 3 shared Kevin WuiD· 3 shared Matt McPartloniD· 3 shared Chai Discovery Team· 2 shared Danny Geisz· 2 shared Nathan Rollins· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSynthetic Biology

Alex RogozhnikovORCID

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3 papers

Recent·Most cited

Drug-like antibody design against challenging targets with atomic precision

Chai Discovery Team, Jacques Boitreaud, Robert S. Chen, Jack Dent, Lucy Fairweather, Danny Geisz, Matthew Greenig, Nate Boyd, Jinay Jain, Brady Johnston, Matt McPartlon, Joshua Meier, Neil Patil, Zhuoran Qiao, Alex Rogozhnikov, , Andy Yeung

This paper introduces a computational antibody design platform that generates drug-like antibodies with high developability and atomic accuracy, demonstrating its utility for challenging therapeutic targets.

bioRxiv · Nov 29, 2025 · PreprintMolecular Biology

Zero-shot antibody design in a 24-well plate

Chai Discovery Team, Jacques Boitreaud, Jack Dent, Danny Geisz, Matt McPartlon, Joshua Meier, Zhuoran Qiao, Alex Rogozhnikov, Nathan Rollins, Paul Wollenhaupt, Kevin Wu

This paper introduces Chai-2, a model that designs antibodies with a 16% hit rate, achieving success in 50% of targets without prior binders, and enables rapid validation in under two weeks.

bioRxiv · Jul 5, 2025 · PreprintSynthetic Biology

Chai-1: Decoding the molecular interactions of life

Chai Discovery, Jacques Boitreaud, Jack Dent, Matt McPartlon, Joshua Meier, Vinicius Reis, Alex Rogozhnikov, Kevin Wu

Chai-1 matches AlphaFold3 on PoseBusters ligand poses (77% vs 76%), beats AlphaFold-Multimer 2.3 on low-homology interfaces, and stays competitive without MSAs on multimers and antibodies.

bioRxiv · Oct 10, 2024 · PreprintSynthetic Biology✦ In-depth digest