Genetic screen suggests an alternative mechanism for azide-mediated inhibition of SecA
Rachael Chandler, Mohammed Jamshad, Jack Yule, Ashley Robinson, Farhana Alam, Karl A. Dunne, Naomi Nabi, Ian Henderson, Damon Huber
The paper uses a genetic screen to show azide inhibits SecA by causing it to backtrack in its ATPase cycle, disrupting membrane and metal cofactor binding.
bioRxiv · Aug 22, 2018 · PreprintMicrobiology