Author

Jaclyn Essig

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:electronic health records· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gidon FelseniD· 2 shared Andrew R FieldiD· 1 shared Charlie Harper· 1 shared Jordane DimidschsteiniD· 1 shared Joshua B. HuntiD· 1 shared Joshua Reiser· 1 shared Kathryn C. AllawayiD· 1 shared Lucia CapanoiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Gidon FelsenORCID

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Author profile →

3 papers

Recent·Most cited

PV interneuron-targeted CRISPRa rescue of SCN1A haploinsufficiency in Dravet syndrome

Perry W.E. Spratt, Nicholas F. Trojanowski, Rajani M. George, Olivia Stevenson, Tessa Nottonson, Joshua Reiser, Lucia Capano, Andrew R Field, Jaclyn Essig, Michael Faundo, Yan Hung, Navneet Kaur Matharu, Charlie Harper, Orrin Devinsky, Jordane Dimidschstein, Kathryn C. Allaway

This study uses CRISPR activation to upregulate SCN1A in PV interneurons, improving survival and reducing seizures in Dravet syndrome models.

bioRxiv · Jul 14, 2026 · PreprintNeuroscience

Functional coupling between target selection and acquisition in the superior colliculus

Jaclyn Essig, Gidon Felsen

This study investigates how the superior colliculus couples target selection and acquisition in mice, showing that choice-predictive neurons increase activity during movement and that an attractor model explains the rostral shift in activity during target acquisition.

Journal of Neurophysiology · Sep 22, 2021Peer-reviewedNeuroscience

Inhibitory midbrain neurons mediate decision making

Jaclyn Essig, Joshua B. Hunt, Gidon Felsen

This study investigates how inhibitory midbrain neurons contribute to decision making by testing hypotheses about their role in spatial choice using optogenetics and computational modeling.

Communications Biology · Jun 11, 2021Peer-reviewedNeuroscience