Author

Jacob Marcus

Merck & Co., Inc., Rahway, NJ, USA (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Anna C. StolliD· 1 shared Bang-Lin WaniD· 1 shared Casey L. Mahoney-CraneiD· 1 shared Danny A. BittoniD· 1 shared Drèson L. RusselliD· 1 shared Jennifer FreireiD· 1 shared Jindřich Soukup· 1 shared Jonathan A. SugamiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Anna C. StollORCID

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2 papers

Recent·Most cited

AnNoBrainer, an Automated Annotation of Mouse Brain Images using Deep Learning

Roman Peter, Petr Hrobař, Josef Navratil, Martin Vagenknecht, Jindřich Soukup, Keiko Tsuji, Nestor X. Barrezueta, Anna C. Stoll, Renee C. Gentzel, Jonathan A. Sugam, Jacob Marcus, Danny A. Bitton

AnNoBrainer automates mouse brain image annotation using deep learning, improving accuracy, reproducibility, and efficiency compared to manual methods.

Neuroinformatics · Aug 6, 2024Peer-reviewedNeuroscience

Neuronopathic GBA1 L444P mutation accelerates glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions

Casey L. Mahoney-Crane, Megha Viswanathan, Drèson L. Russell, Rachel A.C. Curtiss, Jennifer Freire, Sai Sumedha Bobba, Sean D. Coyle, Monika Kandebo, Lihang Yao, Bang-Lin Wan, Nathan Galen Hatcher, Sean M. Smith, Jacob Marcus, Laura A. Volpicelli‐Daley

This study shows that the GBA1 L444P mutation increases glucosylsphingosine levels and hippocampal alpha-synuclein inclusions in mice, contributing to synucleinopathy pathology.

Journal of Neuroscience · Dec 7, 2022Peer-reviewedNeuroscience