Jacob Williams

Spatial MALDI-MSI Reveals a Coordinated Vicious Cycle of Oxidative Membrane Damage and Ceramide-Driven Sphingolipid Dysregulation in the Chronically Neuroinflamed Brain

This study uses MALDI-MSI to show that chronic neuroinflammation causes spatial lipidomic changes in rat brains, including oxidative stress and sphingolipid dysregulation, particularly in the hippocampus and white matter.

Age-Dependent Spatiotemporal Remodeling of Brain Sphingolipids During LPS-Induced Neuroinflammation: MALDI-MSI Reveals Accelerated Sphingomyelin Depletion and Sulfatide Accumulation Linked to Mitochondrial Oxidative Stress

This study uses MALDI-MSI to show age-dependent sphingolipid changes in rat brains after LPS, linking sphingomyelin loss and sulfatide gain to mitochondrial stress.