High-fat diet promotes exhaustion-associated T-cell remodeling across vascular and lymphoid tissues in atherosclerosis-prone mice
Pourya Yarahmadi, Yinghua Xie, Diem Thi Ngoc Huynh, Jacquelyn Lai, Qianhui Ling, Xianxi Huang, Patricia K. Nguyen
This study shows that a high-fat diet causes T-cell exhaustion in multiple tissues of atherosclerosis-prone mice, which partially reverses with dietary changes.
bioRxiv · Nov 4, 2026 · PreprintImmunology