Precocious maturation and Purkinje cell dysfunction in the mouse Chd8 haploinsufficient cerebellum
Nicolas Seban, Esteban Merino, Alexa F. D’Ambra, Se Jung Jung, Jade Lin Dunga, Stephanie Lozano, Ethan M. Fenton, Nick Chu, Kiya C. Jackson, Darlene Rahbarian, Aspen Kopley-Smith, Melissa Corea, Karol Cichewicz, Cory S. Ardekani, Evan G. Antzoulatos, , Alex S. Nord
This study examines the effects of Chd8 haploinsufficiency on cerebellar development and function in mice, revealing cell-type-specific transcriptomic and physiological changes.
bioRxiv · Sep 29, 2026 · PreprintNeuroscience