A functional triangle relationship of topoisomerase IIβ, BARD1, and ERK2 in immediate early gene transcription
Heeyoun Bunch, Jaehyeon Jeong, Anh T. Q. Cong, Jaeyeon Jang, Inuk Jung, Keunsoo Kang, Matthew J. Schellenberg
The paper identifies a functional regulatory circuit involving TOP2B, BARD1, and ERK2 in IEG transcription, showing how their interactions are modulated by ubiquitination and phosphorylation.
bioRxiv · Apr 23, 2026 · PreprintMolecular Biology