Molecular BiologybioRxivPreprint
DNA topological regulation by topoisomerase IIβ-DNA-PK interaction is important for controlled hypoxia-inducible gene expression
Heeyoun Bunch, Jihye Park, Jasper K. Solverson…·Anthony J. Davis
The paper shows that TOP2B and DNA-PK regulate hypoxia-inducible gene expression through DNA topology changes, with DNA-PK phosphorylating TOP2B to control its activity.
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