Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour
Meryam Beniazza, Masahito Yoshihara, Daniel F. Kaemena, James Ashmore, Suling Zhao, Michael R. O’Dwyer, Emil Andersson, Victor Olariu, Shintaro Katayama, Abdenour Soufi, Kosuke Yusa, Keisuke Kaji
This paper identifies Hic2 as a gene that enhances iPSC generation by suppressing KLF4-dependent epidermal gene expression during reprogramming.
bioRxiv · Sep 11, 2025 · PreprintDevelopmental Biology