Hemodynamic Signals Reshape Biological Inference in Widefield Calcium Imaging
Tenesha Connor, Macit Emre Lacin, James Hartz, Miguel Maldonado, Kemal Ozdemirli, Anthony R. Sloan, Justin D. Lathia, sarah muldoon, Murat Yıldırım
This study shows hemodynamic correction significantly alters biological interpretations of cortical dynamics in calcium imaging by reducing global connectivity and changing network structure.
bioRxiv · Jul 9, 2026 · PreprintNeuroscience