Transcriptome remodeling contributes to epidemic disease caused by the human pathogen Streptococcus pyogenes
Stephen Beres, Priyanka Kachroo, Waleed Nasser, Randall Olsen, Luchang Zhu, Anthony Flores, Ivan de la Riva, Jesus Paez-Mayorga, Francisco Jimenez, Concepcion Cantu, Jaana Vuopio, Jari Jalava, Karl Kristinsson, Magnus Gottfredsson, Jukka Corander, , James Musser
This study identifies horizontal gene transfer events in Streptococcus pyogenes that led to a more virulent genotype, causing epidemic disease through transcriptome remodeling and altered host-pathogen interactions.
mBio · Jul 6, 2016Peer-reviewedEvolutionary Biology