A full-length single nuclei transcriptomic atlas of human skeletal muscle insulin resistance
Katie L. Whytock, Adeline Divoux, James Vazquez, Meghan E. Hopf, Mark R. Viggars, Miguel A. Gutierrez‐Monreal, Courtney H. Ruggiero, Felix R. Jimenez, Francielly Morena, Polina M. Krassovskaia, Nicholas T. Broskey, Yifei Sun, Martin J. Walsh, Robert J. Cousins, Joseph A. Houmard, , Bret H. Goodpaster
The paper generates a nucleus-resolved transcriptomic atlas of skeletal muscle insulin resistance using single-nucleus transcriptomics and stable isotope-labeled clamps, identifying cell-specific molecular programs and targets.
bioRxiv · Feb 28, 2026 · PreprintMolecular Biology