Mark R. Viggars

This study shows that inducing mitochondrial permeability transition (mPT) in skeletal muscle mimics key features of cancer cachexia and other wasting conditions, suggesting mPT as a potential therapeutic target.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

The paper profiles multi-omic changes in abdominal subcutaneous adipose tissue after acute exercise in sedentary adults, identifying distinct molecular programs and candidate exerkines.

The paper generates a nucleus-resolved transcriptomic atlas of skeletal muscle insulin resistance using single-nucleus transcriptomics and stable isotope-labeled clamps, identifying cell-specific molecular programs and targets.

This study identifies changes in the skeletal muscle nuclear proteome after acute exercise, revealing post-transcriptional effects on mRNA processing and splicing.

This study quantifies skeletal muscle proteome changes over time in rats during resistance training, revealing distinct adaptation phases driven by ribosomal and mitochondrial protein dynamics.

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

This study shows that BMAL1 in skeletal muscle is essential for transcriptional responses to exercise and peripheral tissue adaptations, with its loss leading to divergent transcriptomic and metabolomic changes and increased inflammation.

The paper compares transcriptional responses to resistance exercise in rats and mice, finding conserved pathways but species-specific differences in energy metabolism.