BiochemistryAntibioticsPeer-reviewed
Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib
Jan Sklenicka, Tung Tran, María Soledad Ramirez…·Marcelo E. Tolmasky
This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.