María Soledad Ramirez

This study develops a mechanism-based pharmacokinetic/pharmacodynamic model to evaluate PMB-based combination therapy against CRKP, showing synergistic effects with lower PMB doses.

This study identifies emerging resistance in KPC variants of K. pneumoniae to CZA, FDC, and FPZ, with mutations in specific regions linked to collateral resistance.

This study investigates the molecular mechanisms of cefiderocol resistance and antagonism with avibactam and sulbactam in carbapenem-resistant Acinetobacter strains.

This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.

This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.