Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-G-F Knock in Mouse Model
Mariam Okhovat, Cora E. Layman, Brett A. Davis, Alexandra Pederson, Abigail O’Niel, Sarah J. Holden, Kat Kessler, Sonia N. Acharya, Kandace J. Wheeler, Kimberly A. Nevonen, Jarod Herrera, Samantha Ward, Katinka A. Vigh‐Conrad, Andrew Adey, Jacob Raber, Lucia Carbone
This study identifies epigenetic and transcriptomic changes in the hippocampus and blood of an Alzheimer's mouse model before amyloidosis onset, suggesting blood methylation as a potential biomarker.
Scientific Reports · Dec 29, 2025Peer-reviewedMolecular Biology