Jayamanna M. Wickramasinghe

This study investigates immune suppression during torpor in 13-lined ground squirrels using single-cell RNA sequencing and image analysis, identifying metabolic and lineage-specific programs that conserve energy while preserving immune function.

This study identifies RSAD2 and CMPK2 as key regulators of EBV reactivation and host interferon responses, revealing their coordinated immunometabolic role in viral latency and immune control.

ERVmancer is a phylogeny-informed method that resolves read-mapping ambiguity for HERVs, outperforming existing approaches and revealing new biology in breast cancer.

This study identifies microbiome-derived protein biomarkers for predicting immunotherapy response and toxicity in melanoma without relying on taxonomic classification.

This study shows chemotherapy induces IL1β-dependent neutrophil recruitment, promoting chemoresistance in metastatic ovarian cancer through NETs and immune modulation.

The paper shows LANA binding at KSHV TRs causes R-loops and histone modifications linked to episome maintenance.

This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.

The paper reconstructs a sparsely interconnected transcriptional hierarchy in leukemia cells stabilized by incoherent feed-forward loops and shows inhibitors disrupt core regulators' programs.

The paper develops viRNAtrap, a deep learning-based pipeline to identify and characterize viral expression in cancer, revealing new viruses and endogenous viruses linked to poor survival.

The paper identifies a modular core regulatory circuitry in AML that enforces oncogene expression in KMT2A-rearranged leukemias.