Jackson Chen

B-cell follicles of lymphatic tissues act as a critical microanatomical niche for sustained viral replication, virus-host interaction and damage during chronic SIV infection

The paper shows that in chronic SIV infection, viral RNA is mainly found in B-cell follicles of lymphatic tissues, leading to structural damage and sustained virus-host interactions.

Mechanistic Investigation of Reversible Hibernation-Driven Immune Suppression in Thirteen-Lined Ground Squirrels

This study investigates immune suppression during torpor in 13-lined ground squirrels using single-cell RNA sequencing and image analysis, identifying metabolic and lineage-specific programs that conserve energy while preserving immune function.

Analysis of SIV Spatiotemporal Dissemination Patterns in Rhesus Macaques During Early Rectal Transmission Demonstrates Systemic Infection Does Not Require Viral Local Amplification at the Entry Portal

This study examines SIV dissemination in rhesus macaques after rectal infection, showing systemic infection occurs without local viral amplification at the entry site.