The Salmonella effector SspH2 disrupts F-actin cytoskeletal organization to inhibit macrophage migration
Una Deng, Melissa Gonzalez, Rose Mera, Ji'Shuri Johnson, Alondra Mancillas, Natasha Sánchez, Jayme Angelo, Leah Hernandez, Ramiro Hernandez, Kristen Weber, Manuel Ricardo Amieva, Denise M. Monack, Laura M. McLaughlin
This study shows that SspH2, an effector of Salmonella, inhibits macrophage migration by disrupting F-actin cytoskeletal organization through E3 ligase activity and vinculin interactions.
bioRxiv · Oct 16, 2026 · PreprintMicrobiology