The Mitochondria-Modulating Small Molecule TEM1657 Suppresses NFKBIZ Pathway and Resolves Th17-Driven Psoriatic Inflammation
Preeti Gautam, Aleksander Salwiński, Ahmed B Abdelwahab, Gaël Jalce, Laura Boulangé, Jessica Bettinger, Jordan Brouard, Alizée Etlicher, Romain Perouf, Julia Halper, Marie Millard, N. de Isla, Paul Hannewald, Jean-Francois GINGLINGER, Marie-Therese RUBIO, , David Moulin
The paper identifies TEM1657, a small molecule that modulates mitochondria and suppresses NFKBIZ pathway to resolve Th17-driven psoriatic inflammation.
bioRxiv · Oct 10, 2026 · PreprintImmunology