Receptor Allostery Promotes Context-Specific Sonic Hedgehog Signaling During Embryonic Development
Shariq S. Ansari, Miriam E. Dillard, Mohamed Ghonim, Yan Zhang, Daniel P. Stewart, Robin Canac, Ivan P. G. Moskowitz, William C. Wright, Christina A. Daly, Shondra M. Pruett‐Miller, Jeffrey Steinberg, Yong‐Dong Wang, Taosheng Chen, Paul Glyndwr Thomas, James P. Bridges, Stacey K. Ogden
This study identifies an arachidonic acid binding pocket in SMO that modulates SHH signaling, revealing context-specific allostery crucial for cardiopulmonary development.
bioRxiv · Jan 28, 2025 · PreprintDevelopmental Biology