Epigenetic regulators partition the genome by evolutionary and developmental constraint
Yusuke Kijima, JoAnne Villagrana, Minming Wang, Rosaria Tornisiello, Nicolas Dias, Tien-Chi Jason Hou, Kevin Y. Tse, Jennifer Wang, Helene Kretzmer, Kaelyn Sumigray, Tuğçe Aktaş, Zachary D. Smith
The paper uses single-cell RNA sequencing to analyze mutant phenotypes of epigenetic regulators in mouse embryos, revealing how these regulators partition the genome based on developmental and evolutionary constraints.
bioRxiv · Oct 5, 2026 · PreprintDevelopmental Biology