CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2+ macrophages and CD8 T-cells
Jesus Jimenez, Junedh Amrute, Pan Ma, Xiaoran Wang, Raymond Dai, Kory J. Lavine
This study shows CD40 agonists promote myocardial inflammation by activating CCR2+ macrophages and CD8 T-cells, leading to heart failure.
bioRxiv · Mar 14, 2024 · PreprintImmunology