Adaptive thermogenesis is mediated by GDF15 via the GFRAL neuronal axis in mice
Ji Eun Kim, Sang Hyeon Ju, Min Hee Lee, Hyun Jung Hong, Uzma Yaseen, Jung Tae Kim, Benyuan Zhang, Hyon‐Seung Yi, Seong Eun Lee, Yea Eun Kang, Yoon-Sun Yi, Sangmi Jun, Minsung Park, Jinkuk Kim, Johan H. Auwerx, , Minho Shong
This study identifies the GFRAL neuronal axis as critical for GDF15-mediated adaptive thermogenesis in white adipose tissue under mitochondrial stress.
bioRxiv · Jan 15, 2024 · PreprintMolecular Biology