T50 O-GlcNAc PKM2 promotes aerobic glycolysis and PDAC progression via ARNT-CDC27-AKT pathway
Bin Yang, Yi Zhu, Xiaopeng Zhan, Yun Zhang, Jianing Cui, Yu Zhou, Shikai Zhu
This study identifies an O-GlcNAc modification on PKM2 that promotes PDAC progression through the ARNT-CDC27-AKT pathway by enhancing aerobic glycolysis.
bioRxiv · Jul 29, 2026 · PreprintCancer Biology