Yun Zhang

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

This study identifies an O-GlcNAc modification on PKM2 that promotes PDAC progression through the ARNT-CDC27-AKT pathway by enhancing aerobic glycolysis.

This study identifies smoking-associated natural killer cell subsets in NSCLC that correlate with survival and response to neoadjuvant chemoimmunotherapy, suggesting their use in therapeutic stratification.

This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.

The paper expands the kineTAC toolbox by creating 81 new cytokine receptor-targeting chimeras for cell-type-specific extracellular protein degradation.

This study evaluates the efficacy of anticancer peptides in patient-derived organoids of intrahepatic cholangiocarcinoma, showing their potent anti-tumour effects through direct membrane disruption and apoptosis induction.

This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.

The paper introduces a data-driven method to extend cell ontologies for multi-modal single-cell omics data, focusing on the Primary Motor Cortex in humans, mice, and marmosets.

FR-Match matches query single-cell RNA-sequencing datasets to reference atlases to identify common and novel cell types and suboptimally clustered cells with high accuracy.

NS-Forest identifies minimal marker gene combinations for cell type determination from scRNA-seq data, revealing key roles of signaling and non-coding RNAs in neuronal identity.

This study performs whole-genome sequencing on an advanced case of small-cell gallbladder neuroendocrine carcinoma to identify genetic alterations and potential biomarkers.