Differential Nucleotide Inhibition Profile of Mouse and Human UCP1 Expressed in Liver Mitochondria Is Associated with an F88S Mutation
Irina G. Shabalina, Luise Jacobsen, Glauber Rudá Feitoza Braz, Zhiwei Zeng, Naren Qimuge, Björn Eriksson, Uzair Ali, Jiaping Li, Annika Ericsson, Barbara Cannon, Himanshu Khandelia, Jan Nedergaard
This study compares the bioenergetic properties of human and mouse UCP1 expressed in liver mitochondria, revealing differences in nucleotide regulation linked to an F88S mutation.
bioRxiv · Aug 20, 2026 · PreprintBiochemistry