Structural and Functional Insights into HBx-Smc6 Targeting for HBV Inhibition
Tong Cheng, Jinhong Zhou, Wen Huang, Lili Du, Pengyu He, Renzheng Yang, Yan Gao, Menghan Hao, Kongying Hu, Jieliang Chen, Hongxia Wang, Zihe Rao, Zhenghong Yuan, Lanfeng Wang
This study determines the structure of the HBx-CRL4-Smc5/6 complex and identifies a druggable interface for antiviral therapy against HBV.
Cell Research · Apr 16, 2026Peer-reviewedCell Biology