BiochemistrybioRxivPreprint
Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutations
Yuqing Zhang, Jinhan Zhou, Yuping Tan…·Qingxiang Sun
This study shows that destabilizing the C-terminus of Ran promotes GTP loading and is associated with cancer mutations, suggesting a new mechanism for cellular transformation and potential drug targets.
DOI 10.1101/305177