Qingxiang Sun

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

This study shows that KPT-330 initially protects against bacterial pneumonia but later causes severe lung injury and death, with antibiotic adjunctive therapy improving survival.

This study identifies new CRM1 binding sites and structural features of the NES-binding groove using plumbagin and oridonin, revealing potential mechanisms for CRM1 inhibition.

This study shows that destabilizing the C-terminus of Ran promotes GTP loading and is associated with cancer mutations, suggesting a new mechanism for cellular transformation and potential drug targets.