TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition
Assim Verma, Garvit Kumar, Nitin Khandelwal, Benjamin E. Mayer, Jitender Rathee, Yogesh Chander, Alka Nokhwal, Shweta Dhanda, Ram Kumar, Himanshu Kamboj, Riyesh Thachamvally, Shalini Sharma, Naveen Kumar
This paper shows that SB431542, a TGF-β inhibitor, suppresses SARS-CoV-2 replication through three mechanisms: disrupting ORF3a function, inhibiting lysosomal biogenesis, and blocking TGF-β-induced apoptosis, with no resistance observed after 50 generations of exposure.
bioRxiv · Mar 20, 2025 · PreprintMicrobiology