Assim Verma

This paper shows that SB431542, a TGF-β inhibitor, suppresses SARS-CoV-2 replication through three mechanisms: disrupting ORF3a function, inhibiting lysosomal biogenesis, and blocking TGF-β-induced apoptosis, with no resistance observed after 50 generations of exposure.

The paper shows that a mutation in poxviral VP39 enhances mRNA stability and translation efficiency by bypassing feedback inhibition.

This study shows that p38-MAPK is essential for SARS-CoV-2 replication, as its inhibition reduces viral growth and its activation supports RNA/protein synthesis without affecting viral entry or budding.