Small cytosolic dsDNAs repress cGAS activation and induce autophagy
Yao Liu, Xiao Chen, Yuemei Zhao, Xingyue Wang, Lina Chen, Weiyun Wang, Shouhui Zhong, Meizhen Hu, Zhizheng Dai, Jiayu Jiang, Xiaoxiao Cheng, Jiwei Zuo, Hui Liu, Di Ma, Xin Wang, , Kai-Fu Tang
The paper identifies small cytosolic DNAs (scDNAs) that inhibit cGAS activation and induce autophagy, preventing excessive inflammation.
bioRxiv · Jun 30, 2022 · PreprintMolecular Biology