Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies
Samir Zaidi, Jooyoung Park, Joseph Minhow Chan, Martine P. Roudier, Jimmy L. Zhao, Anuradha Gopalan, Kristine M. Wadosky, Radhika A. Patel, Erolcan Sayar, Wouter R. Karthaus, D. Henry Kates, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Linas Mažutis, , Charles L. Sawyers
The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.
Proceedings of the National Academy of Sciences · Jul 5, 2024Peer-reviewedCancer Biology