Pharmacology & ToxicologyNucleic Acid TherapeuticsPeer-reviewed
Rat and rabbit whole embryo culture as a new approach method for unlabeled therapeutic antisense oligonucleotide hazard identification with no requirement for microinjection or assisted transfection
Sara M Bender, Sharon Chapman, Sreenivas Nannapaneni…·Dinesh Stanislaus
This paper shows that rat and rabbit whole embryo culture can identify developmental hazards of antisense oligonucleotides without microinjection or transfection, using mipomersen as a test case.
DOI 10.1177/21593337261442471