Fidgetin-like 2 is a novel negative regulator of axonal growth and can be targeted to promote functional nerve regeneration after injury.
Lisa M. Baker, Moses Tar, G. Villegas, Rabab A. Charafeddine, Adam H. Kramer, Olga Vafaeva, Parimala Nacharaju, Joel Friedman, Kelvin Paul Davies, David J. Sharp
This study identifies FL2 as a negative regulator of axonal growth and shows that targeting it with siRNA promotes nerve regeneration in a rodent model of peripheral nerve injury.
bioRxiv · Mar 19, 2020 · PreprintNeuroscience