Semaglutide engages distinct brainstem-to-hypothalamus circuits to suppress motivated feeding and regulate ketogenesis and energy expenditure
Sebastian Blid Sköldheden, Júlia Teixidor-Deulofeu, Johan Ruud, Linda Engström
This study identifies brainstem-to-hypothalamus circuits through which semaglutide regulates feeding and metabolism by suppressing AgRP neuron activation and modulating energy expenditure and ketogenesis.
bioRxiv · Sep 8, 2026 · PreprintNeuroscience