Author

John Connelly

NHS Lothian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ailith EwingiD· 1 shared Aisling M. RedmondiD· 1 shared Amiel R Hudley· 1 shared Beverly L. DavidsoniD· 1 shared Bryan P. SimpsoniD· 1 shared Christine FeigiD· 1 shared Christopher M. Fluta· 1 shared Christopher P. CaliiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperGenomics

Ailith EwingORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Computational modeling and preclinical validation support targeting somatic instability for Huntington's disease treatment

Bryan P. Simpson, Paul T. Ranum, David E. Leib, Luis Tecedor, Ryan C Giovenco, Icnelia Huerta-Ocampo, Amiel R Hudley, Noah A. Smith, Christopher M. Fluta, Christopher P. Cali, Jamie D. Benoit, Jenna Carroll Soper, John Connelly, George J. Yohrling, Paiman Peter Ghoroghchian, , Beverly L. Davidson

The paper develops a computational model to predict therapeutic benefits of reducing somatic instability in Huntington's disease and validates it with preclinical experiments.

Nature Communications · Oct 28, 2026Peer-reviewedNeuroscience

Genetic background sets the trajectory of cancer evolution

Sarah J. Aitken, Frances Connor, Christine Feig, Tim F. Rayner, Margus Lukk, Juliet Luft, Stuart Aitken, Claudia Arnedo-Pac, J.V. Hayes, Michael D. Nicholson, Ailith Ewing, Vasavi Sundaram, Jan C. Verburg, John Connelly, Craig J. Anderson, , Duncan T. Odom

This study shows that genetic background and environmental factors determine the trajectory of cancer evolution in mice, with distinct mutational paths despite similar final tumor states.

Nature · Jul 22, 2026Peer-reviewedGenomics