G4 RNA inhibits PRC2 by sequestering two disordered loops required for nucleosome binding
John D Houslay, Neil Justin, Richard G. Jenner, Jon R. Wilson, Steve J. Gamblin
This study shows G4 RNA inhibits PRC2 by binding to disordered loops in EZH2, preventing nucleosome interaction and modulated by SAM and peptides.
bioRxiv · Oct 28, 2026 · PreprintBiophysics