Immune receptor LAG3 regulates microglia function duringAlzheimer's disease
Andrew T. Perl, Juan Wu, John D. Dong, Ashley M. Brooks, Andrew R. Yoblinski, Tia T. Vierling, Jian‐Liang Li, Dana R Ruby, Daniel Radzicki, Serena M. Dudek, Jesse D. Cushman, Elizabeta Gjoneska
This study shows that deleting the immune receptor Lag3 in a familial AD mouse model reduces amyloidosis, microgliosis, and behavioral deficits, suggesting Lag3 as a potential therapeutic target for Alzheimer's disease.
Neurobiology of Disease · May 12, 2026Peer-reviewedNeuroscience