Sperm development requires TMC5-dependent mechanoresponsive calcium entry
Wenxuan Sharon Zheng, Wenxuan Sharon Zheng, John Duncan, Liam James McFarlin Slocomb, Liam James McFarlin Slocomb, Michelina Kierzek, Fan Lin, Alexander Webb, Erin Jeffery, Celia Maria Santi, Jung-Bum Shin, Sameer S. Bajikar, Gloria Sheynkman, Bimal N. Desai, Brian P. Hermann, , Seham Ebrahim
This study identifies TMC5 as essential for mechanoresponsive calcium entry during spermiogenesis, linking mechanical cues to sperm development and male infertility.
bioRxiv · Sep 28, 2026 · PreprintCell Biology