Author

John Szpyt

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:database / resource· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Devin K. SchweppeiD· 2 shared Steven P. GygiiD· 2 shared Alexandra M. ThornockiD· 1 shared Alexandra PanoviD· 1 shared Arvene Golbazi· 1 shared Brandon M. GassawayiD· 1 shared David P. NusinowiD· 1 shared Edward L. HuttliniD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Devin K. SchweppeORCID

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2 papers

Recent·Most cited

Global and tissue-specific aging effects on murine proteomes

Gregory R. Keele, Jigang Zhang, John Szpyt, Ron Korstanje, Steven P. Gygi, Gary A. Churchill, Devin K. Schweppe

The paper analyzes proteomic changes across 10 tissues in mice at different ages, finding age-related increases in immune proteins and tissue-specific alterations in protein complexes.

Cell Reports · Jul 1, 2023Peer-reviewedSystems Biology

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, José Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra M. Thornock, Gabriela Zárraga-Granados, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, , Steven P. Gygi

The paper creates two large-scale cell-line-specific human interactomes using affinity-purification mass spectrometry and identifies shared and cell-specific protein interactions.

Cell · May 1, 2021Peer-reviewedSystems Biology