Modular assembly of mitochondrial complex III from a dynamic matrix domain pool
Jorge Jimenez-Niebla, Rhoshan Jha, Christophe Wirth, Jon V. Busto, Antoine Feignier, Miguel Cosenza-Contreras, Katharina Ruoff, Manuel Dorer, Riccardo Babic, Friedel Drepper, Claudine Kraft, Pitter F. Huesgen, Nils Wiedemann, Wei-Chun Kao, Carola Hunte
This study reveals how mitochondrial complex III assembles from preformed matrix domain modules, showing dynamic subunit exchange and the role of specific residues in assembly and disease.
bioRxiv · Nov 9, 2026 · PreprintBiochemistry