Author

Manuel Dorer

Biochemistry and Functional Proteomics, Faculty of Biology, University of Freiburg, Freiburg, Germany

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Friedel DrepperiD· 2 shared Katharina RuoffiD· 2 shared Pitter F. HuesgeniD· 2 shared Anna Morath· 1 shared Antoine Feignier· 1 shared Balbino AlarcóniD· 1 shared Bjoern Lillemeier· 1 shared Carola HunteiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Friedel DrepperORCID

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Author profile →

2 papers

Recent·Most cited

Modular assembly of mitochondrial complex III from a dynamic matrix domain pool

Jorge Jimenez-Niebla, Rhoshan Jha, Christophe Wirth, Jon V. Busto, Antoine Feignier, Miguel Cosenza-Contreras, Katharina Ruoff, Manuel Dorer, Riccardo Babic, Friedel Drepper, Claudine Kraft, Pitter F. Huesgen, Nils Wiedemann, Wei-Chun Kao, Carola Hunte

This study reveals how mitochondrial complex III assembles from preformed matrix domain modules, showing dynamic subunit exchange and the role of specific residues in assembly and disease.

bioRxiv · Nov 9, 2026 · PreprintBiochemistry

An ER Retrieval-and-Release System Reveals Ligand-Independent Basal Signaling by Cell Surface TCRs

Claudia Juraske, Simon Beyer, Sara Hartmann, Daniel Peschkov, Emmanuelle Moraes Ribeiro, Hamidreza Ebrahimiyan, Katharina Ruoff, Felix Rainer Schmid, Anna Morath, Manuel Dorer, Friedel Drepper, Balbino Alarcón, Gina Fiala, Mohsen Basiri, Bjoern Lillemeier, , Wolfgang Schamel

The paper develops an ER retrieval-and-release system to study ligand-independent basal TCR signaling, finding that surface TCRs generate distinct phosphorylation patterns compared to ligand-induced activation.

bioRxiv · Oct 14, 2026 · PreprintImmunology