Design of Orthogonal Far-Red, Orange and Green Fluorophore-binding Proteins for Multiplex Imaging
Long Tran, Steffen Klein, David Juergens, Shajesh Sharma, Justin A. Decarreau, Gyu Rie Lee, Yujia Wang, Wei Chen, Asim K. Bera, Alex Kang, Jon Woods, Emily Joyce, Dionne K. Vafeados, Nicole Roullier, Xinting Li, , David A. Baker
The paper designs orthogonal fluorophore-binding proteins using deep learning for multiplex imaging, demonstrating high specificity and utility in labeling and monitoring subcellular processes.
bioRxiv · Aug 3, 2025 · PreprintBiochemistry